RNA Details
Disease Name
kidney diseases
Tissue
kidney
RNA Symbol
mir-136
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
NA
Target
SYK
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
MiR-136 improves renal fibrosis in diabetic rats by targeting down-regulation of tyrosine kinase SYK and inhibition of TGF-beta1/Smad3 signaling pathway
Year
2020
Function
"Syk activates TGF-beta/smad3 signaling, while miR-136 inhibits TGF-beta/smad3 signaling mediating tubular epithelial cell fibrosis by down-regulating syk."